Journal of Liver Cancer

Je Han Won

2 Articles

A Case of Complete Remission of Advanced Hepatocellular Carcinoma with Intra-arterial Chemotherapy: Kee Myung Lee, Je Han Won, Sung Woo Kim, Jae Geun Kim, So Yoon Park, Kwang Hyeon Ko, Sung Won Cho; Journal of the Korean Liver Cancer Study Group. 2001;1(1):103-106. Published online June 30, 2001

Abstract PDF: A 44 year-old-male patient was admitted to our hospital for evaluation of hepatic mass which was detected on ultrasonography. On serologic and tumor marker study, HBeAg was positive, AFP was 570 mg/mL. Liver function test was normal. Abdomen CT showed less enhanced hepatic mass on 4, 5 and left portal vein thrombosis. Hepatocellular carcinoma was confirmed with biopsy and we treated the patient with transarterial chemoembolization (TACE). CT scan taken 2 weeks after TACE showed the aggravation of portal vein thrombosis and Lipiodol was washed out. After 1 month after TACE, we could not perform any more TACE because portogram showed both portal veins were occluded. CT showed new mass on S 6. We inserted chemoport catheter to proper hepatic artery and started intra-arterial chemotherapy(5-FU 250 mg and cisplatin 10 increased. But after the 2nd cycle of IACT, tumor size was decreased and after the 3rd cycle tumor on S 6 was disappeared. After the 4th cycle, tumor on S 4, 5 was disappeared. We have tried totally 6 cycles of IACT　and CT taken after the 6th IACT showed no tumor mass and no portal vein thrombosis. Serum AFP level was rapidly dropped and remained less than 2.0 ng/dL after the 4th cycle. We followed the patient for 14 months after the 6th cycle and there was no evidence of residual tumor with image and tumor marker study.

A Case of Advanced Hepatocellular Carcinoma with Inferior Vena Cava and Right Atrium Invasion Treated with Intra-arterial Chemotherapy: Kee Myung Lee, Je Han Won, Deok Kee Kim, Jae Geun Kim, Won Seok Kim, Kwang Hyeon Ko, Sung Won Cho; Journal of the Korean Liver Cancer Study Group. 2001;1(1):107-109. Published online June 30, 2001

Abstract PDF: A 52 year-old-male patient was admitted to our hospital due to hematemesis. Ten years ago, he had been diagnosed chronic hepatitis B and he was heavy alcoholics. He was in the state of SB tube insertion and we had esophagogastroduodenoscopy and found out cardiac varix bleeding and injected history1. On abdominal ultrasonograpy, large hypoechoic mass in left lobe of liver was noted and the mass invaded into hepatic vein, inferior vena cava (IVC), and right atrium. On hepatic arteriography, large hypervascular mass in left lobe of the liver and several small dodules in right lobe were noted. We performed chemoembolization to the nodules in right lobe but cannot performed to the lesion in left love due to arteriovenous shunt. We inserted the chemport catheter to proper hepatic artery and started the intra-arterial chemotherapy (IACT) with 5-FU 250 mg and cisplatin 10 mg for 5 days. After the second cycle of IACT, tumor thrombus in right atrium was disappeared and thrombus in IVC and tumor mass in left lobe were decreased in size. We believed that hepatocellular carcinoma of this patient should be sensitive to chemotherapy and planned the additional IACT treatment.